ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.

Ghai R, Du X, Wang H, Dong J, Ferguson C, Brown AJ, Parton RG, Wu JW, Yang H
Nat Commun. 2017 Oct 2;8(1):757. doi: 10.1038/s41467-017-00861-5. PubMed Article

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