PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.
Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10. PubMed Article
Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 110938 | pLenti6.3-OGDH_wobble | OGDH ORF containing silent wobble mutations insensitive to corresponding shRNAs |
| 110939 | pLKO-puro-tetON-shGFP | Tet-inducible shRNA targeting GFP |
| 110940 | pLKO-puro-tetON-shRFP | Tet-inducible shRNA targeting RFP |
| 110941 | pLKO-puro-tetON-shOGDH 1714 | Tet-inducible shRNA targeting OGDH |
| 110942 | pLKO-puro-tetON-shOGDH 2497 | Tet-inducible shRNA targeting OGDH |
| 110943 | pLKO-puro-tetON-shOGDH 2956 | Tet-inducible shRNA targeting OGDH |