Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of beta-catenin signaling.

Berwick DC, Javaheri B, Wetzel A, Hopkinson M, Nixon-Abell J, Granno S, Pitsillides AA, Harvey K
Mol Neurodegener. 2017 Jan 19;12(1):9. doi: 10.1186/s13024-017-0153-4. PubMed Article

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