The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.

Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH
Nat Immunol. 2017 Jan;18(1):26-35. doi: 10.1038/ni.3618. Epub 2016 Nov 28. PubMed Article

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