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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J
Nature. 2016 Jul 6;535(7610):153-8. doi: 10.1038/nature18629. PubMed Article

Plasmids from Article

ID Plasmid Purpose
80950Flag-GsdmdExpresses Gsdmd in mammalian cells
80951Flag-Gsdmd-NTExpresses Gsdmd-NT in mammalian cells
80952Flag-Gsdmd-NT 4AExpresses Gsdmd-NT 4A mutant in mammalian cells
80953Flag-Gsdmd-CTExpresses Gsdmd-CT in mammalian cells
133887Flag-Gsdmd-NT C39AExpresses Gsdmd-NT mutant in mammalian cells
133888Flag-Gsdmd-NT C57AExpresses Gsdmd-NT mutant in mammalian cells
133889Flag-Gsdmd-NT C77AExpresses Gsdmd-NT mutant in mammalian cells
133890Flag-Gsdmd-NT C122AExpresses Gsdmd-NT mutant in mammalian cells
133891Flag-Gsdmd-NT C192AExpresses Gsdmd-NT mutant in mammalian cells
133892Flag-Gsdmd-NT C265AExpresses Gsdmd-NT mutant in mammalian cells

Antibodies from Article