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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Fei F, Firestone B, Fodor M, Fridrich C, Gao H, Grunenfelder D, Hao HX, Jacob J, Ho S, Hsiao K, Kang ZB, Karki R, Kato M, Larrow J, La Bonte LR, Lenoir F, Liu G, Liu S, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Price E, Quinn C, Shakya S, Shultz MD, Slisz J, Venkatesan K, Wang P, Warmuth M, Williams S, Yang G, Yuan J, Zhang JH, Zhu P, Ramsey T, Keen NJ, Sellers WR, Stams T, Fortin PD
Nature. 2016 Jul 7;535(7610):148-52.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
85457SHP2(WT)@pLKO-Trex-SBPGene expression
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85458SHP2(T253M/Q257L)@pLKO-Trex-SBPSHP2 mutant gene expression
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85459SHP2(C459S)@pLKO-Trex-HAExpresses SHP2 mutant in mammalian cells
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Antibodies from Article