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Sestrin2 is a leucine sensor for the mTORC1 pathway.
Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM
Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
73670pRK5-FLAG-Sestrin2-S190Woverexpression
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73671pRK5-FLAG-Sestrin2-L261Aoverexpression
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73672pRK5-HA-Sestrin2-L261Aoverexpression
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73673pRK5-FLAG-Sestrin2-E451Aoverexpression
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73674pRK5-HA-Sestrin2-E451Aoverexpression
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73675pRK5-FLAG-dSestrin (CG11299-PD)overexpression
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73676pLJM1-FLAG-Sestrin2-L261Aoverexpression
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73677pLJM1-FLAG-Sestrin2-E451Aoverexpression
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73678pS2-FLAG-Sestrin2-L261Aoverexpression
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73679pS2-FLAG-Sestrin2-E451Aoverexpression
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Antibodies from Article