Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.

Shen WC, Li HY, Chen GC, Chern Y, Tu PH
Autophagy. 2015 Apr 3;11(4):685-700. doi: 10.4161/auto.36098. PubMed Article

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