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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM
Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
69006pcDNA3-FLAG-MTOR-L1460Pactivating MTOR mutation
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69008pcDNA3-FLAG-MTOR-C1483Factivating MTOR mutation
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69009pcDNA3-FLAG-MTOR-E1799Kactivating MTOR mutation
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69010pcDNA3-FLAG-MTOR-F1888Lactivating MTOR mutation
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69011pcDNA3-FLAG-MTOR-T1977Ractivating MTOR mutation
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69012pcDNA3-FLAG-MTOR-V2006Iactivating MTOR mutation
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69013pcDNA3-FLAG-MTOR-S2215Yactivating MTOR mutation
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69014pcDNA3-FLAG-MTOR-I2500Factivating MTOR mutation
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69015pcDNA3-FLAG-MTOR-R2505Pactivating MTOR mutation
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69017pcDNA3-FLAG-MTOR-D2512Hactivating MTOR mutation
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69018pRK5-HA-GST-4EBP1-Low GCexpresses tagged 4EBP1
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Antibodies from Article