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The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling.

Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, Bovijn C, Tavernier J, Peelman F
J Biol Chem. 2014 Jan 17;289(3):1364-76. doi: 10.1074/jbc.M113.499194. Epub 2013 Dec 2. (Link opens in a new window) PubMed (Link opens in a new window) Article

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