mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo.
Hartman NW, Lin TV, Zhang L, Paquelet GE, Feliciano DM, Bordey A
Cell Rep. 2013 Oct 31;5(2):433-44. doi: 10.1016/j.celrep.2013.09.017. Epub 2013 Oct 17. PubMed Article
Hartman NW, Lin TV, Zhang L, Paquelet GE, Feliciano DM, Bordey A
Cell Rep. 2013 Oct 31;5(2):433-44. doi: 10.1016/j.celrep.2013.09.017. Epub 2013 Oct 17. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 81086 | pSico-shRaptor | conditional expression of an shRNA targeting murine Raptor |
| 81087 | pSico-shRheb | conditional expression of an shRNA targeting murine Rheb |
| 81088 | pSicoR-shS6K1/2 | expresses an shRNA targeting both S6K1 and S6K2 (mouse) |
| 81121 | pSicoR-sh4EBP2 | expresses an shRNA targeting murine 4E-BP2 |
| 81122 | pCAGGS-4EBP1 F113A | expresses a constitutively active mutant of 4E-BP1 under the CAG promoter |