CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity.

Cradick TJ, Fine EJ, Antico CJ, Bao G
Nucleic Acids Res. 2013 Nov;41(20):9584-92. doi: 10.1093/nar/gkt714. Epub 2013 Aug 11. PubMed Article

Plasmids from Article

No plasmids are currently publicly available from Addgene for this article.