Binding of a third metal ion by the human phosphatases PP2Calpha and Wip1 is required for phosphatase activity.

Tanoue K, Miller Jenkins LM, Durell SR, Debnath S, Sakai H, Tagad HD, Ishida K, Appella E, Mazur SJ
Biochemistry. 2013 Aug 27;52(34):5830-43. doi: 10.1021/bi4005649. Epub 2013 Aug 16. PubMed Article

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