Optogenetic mimicry of the transient activation of dopamine neurons by natural reward is sufficient for operant reinforcement.

Kim KM, Baratta MV, Yang A, Lee D, Boyden ES, Fiorillo CD
PLoS One. 2012;7(4):e33612. doi: 10.1371/journal.pone.0033612. Epub 2012 Apr 10. PubMed Article

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