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SUMO2/3 conjugation is an endogenous neuroprotective mechanism.

Datwyler AL, Lattig-Tunnemann G, Yang W, Paschen W, Lee SL, Dirnagl U, Endres M, Harms C
J Cereb Blood Flow Metab. 2011 Nov;31(11):2152-9. doi: 10.1038/jcbfm.2011.112. Epub 2011 Aug 24. (Link opens in a new window) PubMed (Link opens in a new window) Article

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