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Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response.

Gardner BM, Walter P
Science. 2011 Sep 30;333(6051):1891-4. doi: 10.1126/science.1209126. Epub 2011 Aug 18. (Link opens in a new window) PubMed (Link opens in a new window) Article

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