Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T
Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012. PubMed Article
Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T
Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 52057 | pCMV-myc3-Mdm2 D367E | expression of non-cleavable Mdm2 in mammalian cells |
| 52058 | pCMV-myc3-Mdm2 D367A | expression of non-cleavable Mdm2 in mammalian cells |
| 52059 | pCMV-myc3-Mdm2 p60 | expression of truncated Mdm2 in mammalian cells |
| 52061 | MSCV-shCasp2-IRES-GFP | stable knockdown of Caspase-2 in mammalian cells |