Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature.

Atipairin A, Canyuk B, Ratanaphan A
J Biol Inorg Chem. 2011 Feb;16(2):217-26. doi: 10.1007/s00775-010-0718-y. Epub 2010 Oct 22. PubMed Article

Plasmids from Article

No plasmids are currently publicly available from Addgene for this article.