The lack of an inherent membrane targeting signal is responsible for the failure of the matrix (M1) protein of influenza A virus to bud into virus-like particles.

Wang D, Harmon A, Jin J, Francis DH, Christopher-Hennings J, Nelson E, Montelaro RC, Li F
J Virol. 2010 May;84(9):4673-81. doi: 10.1128/JVI.02306-09. Epub 2010 Feb 24. PubMed Article

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