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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y
Science. 2009 Apr 10;324(5924):261-5. doi: 10.1126/science.1170944.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
62906pcDNA3-Flag-IDH1Expresses wildtype IDH1 in mammalian cells
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62907pcDNA3-Flag-IDH1-R132HExpresses R132 mutant IDH1 in mammalian cells
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62923pBabe-puro-Flag-IDH1Retrovirus expression plasmid
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62924pBabe-puro-Flag-IDH1-R132HRetrovirus expression plasmid
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Antibodies from Article