The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation.
Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT
Nat Cell Biol. 2006 Apr . 8(4):348-57. PubMed Article
Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT
Nat Cell Biol. 2006 Apr . 8(4):348-57. PubMed Article
Plasmids from Article
ID | Plasmid | Purpose |
---|---|---|
15100 | V51 pIRESpuro-GLUE (pGLUE) | tandem-affinity purification plasmid; streptavidin-(streptag) and calmodulin-(CBP) binding affinity tags |
15101 | M76 pIRESpuro-GLUE-hDsh2 | |
15102 | M77 pIRESpuro-GLUE-hDsh3 | |
16752 | XE257 pCDNA3.1(zeo)-hDsh3-truncDEP | |
16758 | XE251 pCDNA3.1(zeo)-hDsh3 | |
16761 | XE248 pCDNA3.1+zeo-VSV-KLHL12 |