Xiaolu Yang Lab Materials

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Title	Authors	Publication
A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration.	Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X	Mol Cell. 2014 Jul 3;55(1):15-30. doi: 10.1016/j.molcel.2014.04.030. Epub 2014 May 29.
Assays for the Degradation of Misfolded Proteins in Cells.	Guo L, Prall W, Yang X	J Vis Exp. 2016 Aug 28;(114). doi: 10.3791/54266.
Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.	Hu S, Yang X	J Biol Chem. 2003 Mar 21;278(12):10055-60. Epub 2003 Jan 13.
cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas.	Hu S, Du MQ, Park SM, Alcivar A, Qu L, Gupta S, Tang J, Baens M, Ye H, Lee TH, Marynen P, Riley JL, Yang X	J Clin Invest. 2006 Jan . 116(1):174-81.
Critical role for Daxx in regulating Mdm2.	Tang J, Qu LK, Zhang J, Wang W, Michaelson JS, Degenhardt YY, El-Deiry WS, Yang X	Nat Cell Biol. 2006 Aug . 8(8):855-62.
DAXX represents a new type of protein-folding enabler.	Huang L, Agrawal T, Zhu G, Yu S, Tao L, Lin J, Marmorstein R, Shorter J, Yang X	Nature. 2021 Aug 18. pii: 10.1038/s41586-021-03824-5. doi: 10.1038/s41586-021-03824-5.
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.	Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X	Nat Cell Biol. 2011 Mar;13(3):310-6. Epub 2011 Feb 20.
Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.	Tang J, Agrawal T, Cheng Q, Qu L, Brewer MD, Chen J, Yang X	PLoS One. 2013;8(2):e55813. doi: 10.1371/journal.pone.0055813. Epub 2013 Feb 6.
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.	Jiang P, Du W, Mancuso A, Wellen KE, Yang X	Nature. 2013 Jan 31;493(7434):689-93. doi: 10.1038/nature11776. Epub 2013 Jan 13.
The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation.	Kawadler H, Gantz MA, Riley JL, Yang X	Mol Cell. 2008 Aug 8. 31(3):415-21.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.354.592930.27973	27973	Flag-cIAP2/pRK5	CIAP2 (BIRC3 Human)	Mammalian Expression	cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin Invest. 2006 Jan . 116(1):174-81.
100.4.803595.41521	41521	G6PD/pRK5	glucose-6-phosphate dehydrogenase (G6PD Human)	Mammalian Expression	p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol. 2011 Mar;13(3):310-6. Epub 2011 Feb 20.
50.21.405540.59742	59742	Flag-PML IV/pRK5	PML isoform IV (PML Human)	Mammalian Expression	A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration. Mol Cell. 2014 Jul 3;55(1):15-30. doi: 10.1016/j.molcel.2014.04.030. Epub 2014 May 29.
50.2.350568.39237	39237	Flag-p53/pRK5	p53 (TP53 Human)	Mammalian Expression	p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol. 2011 Mar;13(3):310-6. Epub 2011 Feb 20.
50.1.723708.59743	59743	HA-RNF4/pRK5	RNF4 (RNF4 Human)	Mammalian Expression	A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration. Mol Cell. 2014 Jul 3;55(1):15-30. doi: 10.1016/j.molcel.2014.04.030. Epub 2014 May 29.
50.0.474583.27974	27974	Flag-Daxx/pRK5	Daxx (DAXX Human)	Mammalian Expression	Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 2006 Aug . 8(8):855-62.
20.355.911233.27972	27972	Flag-cIAP1/pRK5	CIAP1 (BIRC2 Human)	Mammalian Expression	Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60. Epub 2003 Jan 13.
20.4.830744.119021	119021	Daxx/pEGFP	death-domain associated protein (Daxx) (DAXX Human)	Mammalian Expression	Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation. PLoS One. 2013;8(2):e55813. doi: 10.1371/journal.pone.0055813. Epub 2013 Feb 6.
20.1.946186.27971	27971	Flag-MALT1-/pRK5	MALT1 (MALT1 Human)	Mammalian Expression	The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation. Mol Cell. 2008 Aug 8. 31(3):415-21.
20.0.749543.52023	52023	HA-Daxx/pRK5	HA-Daxx (DAXX Human)	Mammalian Expression	Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation. PLoS One. 2013;8(2):e55813. doi: 10.1371/journal.pone.0055813. Epub 2013 Feb 6.