Darrell Kotton Lab Materials

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Title	Authors	Publication
Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.	Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN	J Clin Invest. 2010 Jan . 120(1):379-89.
Collective curvature sensing and fluidity in three-dimensional multicellular systems	Tang W, Das A, Pegoraro AF, Han YL, Huang J, Roberts DA, Yang H, Fredberg JJ, Kotton DN, Bi D, Guo M	Nat. Phys. 18, 1371–1378 (2022).
Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells.	Jacob A, Vedaie M, Roberts DA, Thomas DC, Villacorta-Martin C, Alysandratos KD, Hawkins F, Kotton DN	Nat Protoc. 2019 Dec;14(12):3303-3332. doi: 10.1038/s41596-019-0220-0. Epub 2019 Nov 15.
Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.	Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN	Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10. doi: 10.1016/j.stem.2017.08.014. Epub 2017 Sep 28.
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.	McCauley KB, Hawkins F, Serra M, Thomas DC, Jacob A, Kotton DN	Cell Stem Cell. 2017 Jun 1;20(6):844-857.e6. doi: 10.1016/j.stem.2017.03.001. Epub 2017 Mar 30.
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells.	Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN	Cell Stem Cell. 2012 Apr 6;10(4):398-411.
Generation of a Purified iPSC-Derived Smooth Muscle-like Population for Cell Sheet Engineering.	Kwong G, Marquez HA, Yang C, Wong JY, Kotton DN	Stem Cell Reports. 2019 Sep 10;13(3):499-514. doi: 10.1016/j.stemcr.2019.07.014. Epub 2019 Aug 15.
Generation of human alveolar epithelial type I cells from pluripotent stem cells.	Burgess CL, Huang J, Bawa PS, Alysandratos KD, Minakin K, Ayers LJ, Morley MP, Babu A, Villacorta-Martin C, Yampolskaya M, Hinds A, Thapa BR, Wang F, Matschulat A, Mehta P, Morrisey EE, Varelas X, Kotton DN	Cell Stem Cell. 2024 Apr 15:S1934-5909(24)00098-5. doi: 10.1016/j.stem.2024.03.017.
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.	Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN	Stem Cells. 2010 Oct . 28(10):1728-40.
Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters.	Sun YL, Hurley K, Villacorta-Martin C, Huang J, Hinds A, Gopalan K, Caballero IS, Russo SJ, Kitzmiller JA, Whitsett JA, Beers MF, Kotton DN	Am J Respir Cell Mol Biol. 2021 Oct;65(4):442-460. doi: 10.1165/rcmb.2020-0259OC.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.104.958782.49343	49343	pHAGE NFkB-TA-LUC-UBC-GFP-W	eGFP (eGFP ), Luciferase, NFkB consensus binding sequence, TA, UBC	Lentiviral	Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Mol Ther. 2013 Apr;21(4):825-33. doi: 10.1038/mt.2013.19. Epub 2013 Feb 12.
100.19.668804.46793	46793	pHAGE PGK-GFP-IRES-LUC-W	PGK, eGFP (eGFP ), IRES, Luciferase	Lentiviral	Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest. 2010 Jan . 120(1):379-89.
100.9.088674.30205	30205	Cre-IRES-PuroR	Cre recombinase (cre Enterobacteria phage P1)	Mammalian Expression, Lentiviral	Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells. 2010 Oct . 28(10):1728-40.
100.2.921515.49335	49335	pHAGE NFKB-TA-LUC-UBC-dTomato-W	NFkB consensus binding sequence, TA, Luciferase, UBC, dTomato	Lentiviral	Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Mol Ther. 2013 Apr;21(4):825-33. doi: 10.1038/mt.2013.19. Epub 2013 Feb 12.
50.21.626981.80317	80317	pHAGE-RSV-tdTomato-2A-GCaMP6f	tdTomato, GCaMP6f	Lentiviral	Unstable neurons underlie a stable learned behavior. Nat Neurosci. 2016 Oct 10. doi: 10.1038/nn.4405.
50.9.112515.80316	80316	pHAGE-RSV-tdTomato-2A-GCaMP6s	tdTomato, GCaMP6s	Lentiviral	Unstable neurons underlie a stable learned behavior. Nat Neurosci. 2016 Oct 10. doi: 10.1038/nn.4405.
50.0.764654.24526	24526	pHAGE-CMV-dsRed-UBC-GFP-W		Lentiviral	Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. Am J Respir Cell Mol Biol. 2008 Aug . 39(2):133-41.
20.15.673552.126686	126686	pHAGE-EF1aL-eGFP-W	eGFP	Lentiviral	Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells. Nat Protoc. 2019 Dec;14(12):3303-3332. doi: 10.1038/s41596-019-0220-0. Epub 2019 Nov 15.
20.5.769198.80146	80146	pHAGE-RSV-GCaMP6s	GCaMP6s	Lentiviral	Unstable neurons underlie a stable learned behavior. Nat Neurosci. 2016 Oct 10. doi: 10.1038/nn.4405.
20.3.008078.36450	36450	pHAGE hSPC-eGFP-W	human SP-C promoter, eGFP (eGFP )	Lentiviral	Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 6;10(4):398-411.