Ethan Lee Lab Materials

The Ethan Lee Lab has deposited materials at Addgene for distribution to the research community. Addgene is a nonprofit plasmid repository dedicated to improving life science research.

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Title	Authors	Publication
The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling.	Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E	Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z.
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.	Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, Robbins DJ, Lee E, Ahmed Y	Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0.
USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin signaling.	Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, Thorne CA, Ahmed Y, Lee E	Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
	217615	Human USP46	USP46 (USP46 Human)	Mammalian Expression	The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z.
	217618	Human FLAG-WDR20	WDR20 (WDR20 Human)	Mammalian Expression	The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z.
	217619	Human FLAG-UAF1 S170Y	UAF1 (WDR48 Human)	Mammalian Expression	The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z.
	217620	Drosophila Usp46-V5	USP46 (Usp12-46 Fly)	Mammalian Expression	The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0.
	217622	Drosophila Wdr20-V5	WDR20	Mammalian Expression	The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0.
	217624	Human USP47	USP47 (USP47 Human)	Mammalian Expression	USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin signaling. Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7.
	217626	Human V5-USP47	USP47 (USP47 Human)	Mammalian Expression	USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin signaling. Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7.
	217627	Human Myc-XIAP	XIAP (XIAP Human)	Mammalian Expression	USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin signaling. Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7.
	217628	MBP-C5E-6XTUBE	6XTUBE	Bacterial Expression	USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin signaling. Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7.