Monther Abu-Remaileh Lab Materials

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Title	Authors	Publication
An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation.	Scharenberg SG, Dong W, Ghoochani A, Nyame K, Levin-Konigsberg R, Krishnan AR, Rawat ES, Spees K, Bassik MC, Abu-Remaileh M	Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease.	Nyame K, Hims A, Aburous A, Laqtom NN, Dong W, Medoh UN, Heiby JC, Xiong J, Ori A, Abu-Remaileh M	Mol Cell. 2024 Apr 4;84(7):1354-1364.e9. doi: 10.1016/j.molcel.2024.02.006. Epub 2024 Mar 5.
The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase.	Medoh UN, Hims A, Chen JY, Ghoochani A, Nyame K, Dong W, Abu-Remaileh M	Science. 2023 Sep 15;381(6663):1182-1189. doi: 10.1126/science.adg9288.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
	198566	PX458-SPNS1-sg1	SPNS1-sg1 (SPNS1 Human)	Mammalian Expression, CRISPR	An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
	198567	PX458-SPNS1-sg2	SPNS1-sg2 (SPNS1 Human)	Mammalian Expression, CRISPR	An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
	198568	pMXs-3xFlag-SPNS1	SPNS1 with n-terminal 3xFlag (SPNS1 Human)	Mammalian Expression, Retroviral	An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
	198569	pMXs-IRES-blast 3xFlag-SPNS1(E164K)	SPNS1(E164K) with n-terminal 3xFlag (SPNS1 Human)	Mammalian Expression, Retroviral	An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
	198570	pMXs-IRES-blast 3xFlag-SPNS1(R76A)	SPNS1(R76A) with n-terminal 3xFlag (SPNS1 Human)	Mammalian Expression, Retroviral	An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
	198571	pMXs-IRES-blast GFP-SPNS1	SPNS1 with n-terminal 3xFlag-GFP fusion (SPNS1 Human)	Mammalian Expression, Retroviral	An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
	198572	pMXs-IRES-blast GFP-SPNS1(E164K)	SPNS1(E164K) with n-terminal 3xFlag-GFP fusion (SPNS1 Human)	Mammalian Expression, Retroviral	An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19.
	204836	pRK5 BMPS HK318/9EE-6xHis	CLN5 (CLN5 Human)	Mammalian Expression	The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase. Science. 2023 Sep 15;381(6663):1182-1189. doi: 10.1126/science.adg9288.
	204837	pRK5 BMPS WT-TEV-6xHis	CLN5 (CLN5 Human)	Mammalian Expression	The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase. Science. 2023 Sep 15;381(6663):1182-1189. doi: 10.1126/science.adg9288.
	213603	pRK5-PLA2G15-6xHis WT	Phospholipase A2 Group XV (PLA2G15 Human)	Mammalian Expression	Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease. Mol Cell. 2024 Apr 4;84(7):1354-1364.e9. doi: 10.1016/j.molcel.2024.02.006. Epub 2024 Mar 5.