Axel Brunger Lab Materials

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Title	Authors	Publication
A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles.	Gopal N, Leitz J, Wang C, Esquivies L, Pfuetzner RA, Brunger AT	Curr Res Physiol. 2024 Feb 23;7:100121. doi: 10.1016/j.crphys.2024.100121. eCollection 2024.
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.	Arac D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Sudhof TC, Brunger AT	EMBO J. 2012 Feb 14;31(6):1364-78. doi: 10.1038/emboj.2012.26.
A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate.	Zuniga JE, Schmidt JJ, Fenn T, Burnett JC, Arac D, Gussio R, Stafford RG, Badie SS, Bavari S, Brunger AT	Structure. 2008 Oct 8. 16(10):1588-97.
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.	Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Sudhof TC, Brunger AT	Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.
Brunger Lab Plasmids 2024	(unpublished)
Central pore residues mediate the p97/VCP activity required for ERAD.	DeLaBarre B, Christianson JC, Kopito RR, Brunger AT	Mol Cell. 2006 May 19. 22(4):451-62.
Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides.	Lai Y, Fois G, Flores JR, Tuvim MJ, Zhou Q, Yang K, Leitz J, Peters J, Zhang Y, Pfuetzner RA, Esquivies L, Jones P, Frick M, Dickey BF, Brunger AT	Nature. 2022 Mar;603(7903):949-956. doi: 10.1038/s41586-022-04543-1. Epub 2022 Mar 23.
Mechanistic insights into the recycling machine of the SNARE complex.	Zhao M, Wu S, Zhou Q, Vivona S, Cipriano DJ, Cheng Y, Brunger AT	Nature. 2015 Feb 5;518(7537):61-7. doi: 10.1038/nature14148. Epub 2015 Jan 12.
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.	Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT	Neuron. 2017 Aug 2;95(3):591-607.e10. doi: 10.1016/j.neuron.2017.07.004.
Observing isolated synaptic vesicle association and fusion ex vivo.	Leitz J, Wang C, Esquivies L, Peters JJ, Gopal N, Pfuetzner RA, Wang AL, Brunger AT	Nat Protoc. 2024 Jul 2. doi: 10.1038/s41596-024-01014-x.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
50.1.021833.18874	18874	pEGFP-N1-VAPA(1-242)	VAP-A (Vapa Rat)	Mammalian Expression	Structural basis of FFAT motif-mediated ER targeting. Structure. 2005 Jul . 13(7):1035-45.
50.0.352452.12373	12373	pBD-0001	VCP (Vcp Mouse)	Bacterial Expression	Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell. 2006 May 19. 22(4):451-62.
20.1.890209.31602	31602	BoNT/A-LC	BoNT/A LC	Bacterial Expression	A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate. Structure. 2008 Oct 8. 16(10):1588-97.
20.0.167410.18875	18875	pEGFP-N1-VAPA(1-242) K87D/M89D	VAP-A (Vapa Rat)	Mammalian Expression	Structural basis of FFAT motif-mediated ER targeting. Structure. 2005 Jul . 13(7):1035-45.
20.0.144907.12345	12345	pBD-0016	VCP R313K (Vcp Mouse)	Bacterial Expression	Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell. 2006 May 19. 22(4):451-62.
20.0.095031.20173	20173	rNrx1beta(47-299)	Neurexin 1 beta (Nrxn1 Rat)	Insect Expression	Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron. 2007 Dec 20. 56(6):992-1003.
	12281	pBD-0005	VCP K315L (Vcp Mouse)	Bacterial Expression	Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell. 2006 May 19. 22(4):451-62.
	12339	pBD-0071	VCP K251A (Vcp Mouse)	Bacterial Expression	Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell. 2006 May 19. 22(4):451-62.
	12344	pBD-0010	VCP E305Q (Vcp Mouse)	Bacterial Expression	Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell. 2006 May 19. 22(4):451-62.
	12346	pBD-0013	VCP R313A (Vcp Mouse)	Bacterial Expression	Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell. 2006 May 19. 22(4):451-62.