Lukas Dow Lab Materials

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• Pooled Libraries
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Title	Authors	Publication
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.	Sanchez-Rivera FJ, Diaz BJ, Kastenhuber ER, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravarty D, Zhang H, Leslie CS, Lowe SW, Dow LE	Nat Biotechnol. 2022 Feb 14. pii: 10.1038/s41587-021-01172-3. doi: 10.1038/s41587-021-01172-3.
Dow Lab Unpublished Base Editors	(unpublished)
GO: a functional reporter system to identify and enrich base editing activity.	Katti A, Foronda M, Zimmerman J, Diaz B, Zafra MP, Goswami S, Dow LE	Nucleic Acids Res. 2020 Feb 29. pii: 5766653. doi: 10.1093/nar/gkaa124.
Inducible in vivo genome editing with CRISPR-Cas9.	Dow LE, Fisher J, O'Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW	Nat Biotechnol. 2015 Apr;33(4):390-4. doi: 10.1038/nbt.3155. Epub 2015 Feb 18.
Optimized base editors enable efficient editing in cells, organoids and mice.	Zafra MP, Schatoff EM, Katti A, Foronda M, Breinig M, Schweitzer AY, Simon A, Han T, Goswami S, Montgomery E, Thibado J, Kastenhuber ER, Sanchez-Rivera FJ, Shi J, Vakoc CR, Lowe SW, Tschaharganeh DF, Dow LE	Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.6.864037.110841	110841	pLenti-FNLS-P2A-Puro	BE3RA-FNLS	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
50.16.674863.110869	110869	pLenti-FNLS-P2A-GFP-PGK-Puro	BE3RA-FNLS	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
50.9.541520.112675	112675	pLenti-ABERA-P2A-Puro	ABERA	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
50.8.091772.110854	110854	pLenti-U6-tdTomato-P2A-BlasR (LRT2B)	sgRNA scaffold with spacer	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
50.6.489361.110847	110847	pLenti-TRE3G-FNLS-PGK-Puro	BE3RA-FNLS	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
50.0.721222.62191	62191	c3GIC9	humanized S. Pyogenes Cas9	CRISPR	Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol. 2015 Apr;33(4):390-4. doi: 10.1038/nbt.3155. Epub 2015 Feb 18.
20.3.350394.110837	110837	pLenti-Cas9-P2A-Puro	Cas9	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
20.2.924859.110866	110866	pLenti-HF1RA-P2A-GFP-PGK-Puro	Cas9-HF1RA	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
20.0.477381.112673	112673	pLenti-BE4GamRA-P2A-Puro	BE4GamRA	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.
20.0.475292.110872	110872	pLenti-xFNLS-P2A-Puro	xFNLS(3.7)	Lentiviral	Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018 Jul 3. pii: nbt.4194. doi: 10.1038/nbt.4194.

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	ID	Pooled Library	Vector Type	Publication
	179217	Mouse Base Editing Sensor Library	Mammalian Expression, Lentiviral	Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 2022 Feb 14. pii: 10.1038/s41587-021-01172-3. doi: 10.1038/s41587-021-01172-3.
	179218	Human Base Editing Sensor Library	Mammalian Expression, Lentiviral	Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 2022 Feb 14. pii: 10.1038/s41587-021-01172-3. doi: 10.1038/s41587-021-01172-3.
	179219	ALL-PAM sensor Library	Mammalian Expression, Lentiviral	Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 2022 Feb 14. pii: 10.1038/s41587-021-01172-3. doi: 10.1038/s41587-021-01172-3.