Agnel Sfeir Lab Materials

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Title	Authors	Publication
Alternative splicing is a developmental switch for hTERT expression.	Penev A, Bazley A, Shen M, Boeke JD, Savage SA, Sfeir A	Mol Cell. 2021 Apr 6. pii: S1097-2765(21)00228-8. doi: 10.1016/j.molcel.2021.03.033.
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.	Sfeir A, Kabir S, van Overbeek M, Celli GB, de Lange T	Science. 2010 Mar 26;327(5973):1657-61. doi: 10.1126/science.1185100.
Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination.	Mateos-Gomez PA, Gong F, Nair N, Miller KM, Lazzerini-Denchi E, Sfeir A	Nature. 2015 Feb 12;518(7538):254-7. doi: 10.1038/nature14157. Epub 2015 Feb 2.
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.	Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A	Mol Cell. 2023 Oct 8:S1097-2765(23)00753-0. doi: 10.1016/j.molcel.2023.09.026.
Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.	Yeung F, Ramirez CM, Mateos-Gomez PA, Pinzaru A, Ceccarini G, Kabir S, Fernandez-Hernando C, Sfeir A	Cell Rep. 2013 Jun 27;3(6):1847-56. doi: 10.1016/j.celrep.2013.05.032. Epub 2013 Jun 20.
Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance.	Tigano M, Vargas DC, Tremblay-Belzile S, Fu Y, Sfeir A	Nature. 2021 Mar;591(7850):477-481. doi: 10.1038/s41586-021-03269-w. Epub 2021 Feb 24.
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states.	Barry RM, Sacco O, Mameri A, Stojaspal M, Kartsonis W, Shah P, De Ioannes P, Hofr C, Cote J, Sfeir A	Genes Dev. 2022 Feb 24. pii: gad.349039.121. doi: 10.1101/gad.349039.121.
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore.	Pinzaru AM, Kareh M, Lamm N, Lazzerini-Denchi E, Cesare AJ, Sfeir A	Genes Dev. 2020 Dec 1;34(23-24):1619-1636. doi: 10.1101/gad.337287.120. Epub 2020 Oct 29.
RHINO directs MMEJ to repair DNA breaks in mitosis.	Brambati A, Sacco O, Porcella S, Heyza J, Kareh M, Schmidt JC, Sfeir A	Science. 2023 Aug 11;381(6658):653-660. doi: 10.1126/science.adh3694. Epub 2023 Jul 13.
Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation.	Laprade H, Querido E, Smith MJ, Guerit D, Crimmins H, Conomos D, Pourret E, Chartrand P, Sfeir A	Mol Cell. 2020 Jul 2;79(1):115-126.e6. doi: 10.1016/j.molcel.2020.05.005. Epub 2020 Jun 3.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.20.339262.73132	73132	pcDNA 3.1(Hygro) myc-hPolQ-Flag	Polymerase theta (POLQ Human)	Mammalian Expression	Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination. Nature. 2015 Feb 12;518(7538):254-7. doi: 10.1038/nature14157. Epub 2015 Feb 2.
50.29.770401.182590	182590	pHage2-EF1a-TERT-IRES-Puro	hTERT (TERT Human)	Mammalian Expression, Lentiviral	Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation. Mol Cell. 2020 Jul 2;79(1):115-126.e6. doi: 10.1016/j.molcel.2020.05.005. Epub 2020 Jun 3.
20.105.941932.167289	167289	pTRIP-SFFV-mtagBFP-2A RIGI WT	DDX58 (RIGI Human)	Mammalian Expression, Lentiviral	Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance. Nature. 2021 Mar;591(7850):477-481. doi: 10.1038/s41586-021-03269-w. Epub 2021 Feb 24.
20.5.493365.167288	167288	pLenti-RIGI-Apex- T2A-EGFP	DDX58 (RIGI Human)	Mammalian Expression, Lentiviral	Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance. Nature. 2021 Mar;591(7850):477-481. doi: 10.1038/s41586-021-03269-w. Epub 2021 Feb 24.
	73131	pX330(puro) Rosa26-H3F3B	spCas9	Mammalian Expression	Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination. Nature. 2015 Feb 12;518(7538):254-7. doi: 10.1038/nature14157. Epub 2015 Feb 2.
	73135	pLPC Flag-mRAP1	Rap1 (Terf2ip Mouse)	Mammalian Expression	Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science. 2010 Mar 26;327(5973):1657-61. doi: 10.1126/science.1185100.
	73136	pLPC myc-mRAP1	Rap1 (Terf2ip Mouse)	Mammalian Expression	Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science. 2010 Mar 26;327(5973):1657-61. doi: 10.1126/science.1185100.
	73137	pLPC myc-mRAP1 I312R	Rap1 (Terf2ip Mouse)	Mammalian Expression	Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity. Cell Rep. 2013 Jun 27;3(6):1847-56. doi: 10.1016/j.celrep.2013.05.032. Epub 2013 Jun 20.
	73138	pLPC flag-mRAP1 I312R	Rap1 (Terf2ip Mouse)	Mammalian Expression	Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity. Cell Rep. 2013 Jun 27;3(6):1847-56. doi: 10.1016/j.celrep.2013.05.032. Epub 2013 Jun 20.
	166406	pWZL N-Myc-hPOT1_IRES_hygro	hPOT1 (POT1 Human)	Mammalian Expression	Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore. Genes Dev. 2020 Dec 1;34(23-24):1619-1636. doi: 10.1101/gad.337287.120. Epub 2020 Oct 29.