RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.
Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK
Cell. 2012 Sep 14;150(6):1182-95. doi: 10.1016/j.cell.2012.08.005.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 63560 | pCDNA3.1-Flag-H2A | Expression of human H2A tagged with Flag |
| 63562 | pCDNA3.1-Flag-H2A K5-9R | Expression of human H2A with K5R and K9R tagged with Flag |
| 63563 | pCDNA3.1-Flag-H2A K13-15R | Expression of human H2A with K13R and K15R tagged with Flag |
| 63564 | pCDNA3.1-Flag-H2A K118-119R | Expression of human H2A with K118R and K119R tagged with Flag |
| 63565 | pCDNA3.1-Flag-H2A K5-9-118-119-125-127-129R | Expression of human H2A (with multiple Lysine to Arginine point mutations) tagged with Flag |
| 63566 | pCDNA3.1-Flag-H2A K13R | Expression of human H2A with K13R tagged with Flag |
| 63567 | pCDNA3.1-Flag-H2A K15R | Expression of human H2A with K15R tagged with Flag |
| 63568 | pCDNA3.1-Flag-H2A K13-15-118-119R | Expression of human H2A (with multiple Lysine to Arginine point mutations) tagged with Flag |
| 63570 | pETNKI-his-SUMO-RNF168ring (1-189) | Expression of human RNF168 ring domain (residues 1-189) tagged with His-SUMO |