TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization.
Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA
Clin Cancer Res. 2010 Feb 1;16(3):857-66. doi: 10.1158/1078-0432.CCR-09-2604. Epub 2010 Jan 26.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 72419 | TKTL1 | Study the role of aberrant expression of TKTL1 in HNSCC tumorigenesis |