Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y
Science. 2009 Apr 10;324(5924):261-5. doi: 10.1126/science.1170944.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 62906 | pcDNA3-Flag-IDH1 | Expresses wildtype IDH1 in mammalian cells |
| 62907 | pcDNA3-Flag-IDH1-R132H | Expresses R132 mutant IDH1 in mammalian cells |
| 62923 | pBabe-puro-Flag-IDH1 | Retrovirus expression plasmid |
| 62924 | pBabe-puro-Flag-IDH1-R132H | Retrovirus expression plasmid |