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Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM
Cell. 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
61614pLJM5-mDPYDThe mouse Dpyd was used to rescue the human DPYD hairpin affect on EMT
61615pLJM5-I560S-mDPYDThe mouse Dpyd was used to rescue the human DPYD hairpin affect on EMT
61616DPYD-FLAGThe human DPYD was used to study the effect of DPYD expression on EMT
61618DPYS-FLAGTo study the effect of DPYS activity on EMT

Antibodies from Article