Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.

Hansen SK, Parrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T
J Clin Invest. 2002 Sep;110(6):827-33. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
60324	pGL2 HNF4A P2 wt	HNF4A P2 promoter cloned into the pGL2-basic backbone.
60325	pGL2 HNF4A P2 mut	Mutated HNF4A P2 promoter region cloned into the pGL2-basic backbone. The -181 G to A mutation is in a HNF1alpha binding site and cosegregates with MODY.