Cyclin D activates the Rb tumor suppressor by mono-phosphorylation.
Narasimha AM, Kaulich M, Shapiro GS, Choi YJ, Sicinski P, Dowdy SF
Elife. 2014 May 29:e02872. doi: 10.7554/eLife.02872.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 58905 | pCMV HA hRB-wt | mammalian expression of wild type human Rb |
| 58906 | pCMV HA hRb delta CDK | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed |
| 58907 | pCMV HA hRb delta CDK + S230 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S230 restored |
| 58908 | pCMV HA hRB delta CDK + S249 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S249 restored |
| 58910 | pCMV HA hRB delta CDK + T252 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and T252 restored |
| 58911 | pCMV HA hRB delta CDK + T356 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and T356 restored |
| 58912 | pCMV HA hRB delta CDK + T373 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and T373 restored |
| 58913 | pCMV HA hRB delta CDK + S608 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S608 restored |
| 58914 | pCMV HA hRB delta CDK + S612 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S612 restored |
| 58915 | pCMV HA hRB delta CDK + S780 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S780 restored |
| 58916 | pCMV HA hRB delta CDK + S788 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S788 restored |
| 58918 | pCMV HA hRB delta CDK + S807 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S807 restored |
| 58919 | pCMV HA hRB delta CDK + S811 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and S811 restored |
| 58920 | pCMV HA hRB delta CDK + T821 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and T821 restored |
| 58921 | pCMV HA hRB delta CDK + T826 | mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed and T826 restored |