Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.
Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC
J Neurosci. 2005 Jul 27;25(30):6984-96.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 58734 | Rabbit Cav 2.2 W391A pMT2 | expression of rabbit CaV2.2 calcium channels with a mutation (W391) in the α1-interacting domain (AID) in the I-II loop of CaV2.2 |
| 206085 | Cav2.2 W391A pcDNA3 | expression of rabbit Cav2.2 calcium channel with a mutation (W391A) in the ?1-interacting domain (AID) in the I-II loop of Cav2.2 that prevents Beta subunit binding |