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Chemical inhibition of NAT10 corrects defects of laminopathic cells.

Larrieu D, Britton S, Demir M, Rodriguez R, Jackson SP
Science. 2014 May 2;344(6183):527-32. doi: 10.1126/science.1252651. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
59365pICE-FLAG-NAT10-siR-WTPlasmid for constitutive or doxycycline-inducible expression of wild-type human NAT10 resistant to a siRNA. Confers resistance to puromycin. Use T-REx cells for doxycycline-inducible expression.
59366pICE-FLAG-NAT10-siR-G641EPlasmid for constitutive or doxycycline-inducible expression of G641E mutant of human NAT10 resistant to a siRNA. Confers resistance to puromycin. Use T-REx cells for doxycycline-inducible expression.

Antibodies from Article