The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S
Cell Stem Cell. 2014 Jan 2;14(1):40-52. doi: 10.1016/j.stem.2013.11.001. Epub 2013 Nov 14.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 52716 | pMXs-hs-LIN-41 | retroviral expression of human LIN-41 / TRIM71 |
| 52717 | pMXS-hs-3xHA-LIN-41 | retroviral expression of human LIN-41 / TRIM71 with 3 N-terminal HA tags |
| 52718 | pMXs-hs-3xHA-deltaRING-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing a RING domain deletion and 3 N-terminal HA tags |
| 52719 | pMXs-hs-3xHA-deltaBBox-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing deletion of the BBox domain and 3 N-terminal HA tags |
| 52720 | pMXs-hs-3xHA-deltaCoiledCoil-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing deletion of the Coiled Coil domain and 3 N-terminal HA tags |
| 52721 | pMXs-hs-3xHA-deltaFilamin-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing deletion of the Filamin domain and 3 N-terminal HA tags |
| 52722 | pMXs-hs-3xHA-delta6xNHL-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing deletion of the 6xNHL repeats and 3 N-terminal HA tags |
| 52723 | pMXs-hs-3xHA-NHL only-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing only the NHL repeats and 3 N-terminal HA tags |
| 52724 | pMXs-hs-EGR1 | retroviral expression of human EGR1 |
| 52725 | pMXs-hs-3xHA-C12AC15A-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing cysteine to alanine point mutations at cysteine 12 and 15 and 3 N-terminal HA tags |
| 52726 | pMXs-hs-3xHA-7CtoA-LIN-41 | retroviral expression of human LIN-41 / TRIM71 containing cysteine to alanine point mutations of all 7 cysteines in the RING domain and 3 N-terminal HA tags |
| 52727 | pMXS-hs-HMGA2 | retroviral expression of human HMGA2 |
| 52728 | pMXs-hs-NRAS | retroviral expression of human NRAS |
| 52729 | pMXs-hs-KRAS | retroviral expression of human KRAS |
| 52730 | pMXs-hs-HRAS | retroviral expression of human HRAS |
| 52731 | pMXs-hs-CDC34 | retroviral expression of human CDC34 |