Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.
Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Sestan N, Chang BS, Barkovich AJ, Grant PE, Topcu M, Politsky J, Okano H, Piao X, Walsh CA
Science. 2014 Feb 14;343(6172):764-8. doi: 10.1126/science.1244392.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 52296 | pCAG-DN-RFX | Dominant-negatively inhibits RFX (regulatory factor X) transcription factor. Made of mouse RFX1 DNA binding domain (400-527 aa) and C-terminal myc tag. |
| 52297 | pCAG-hGPR56-IRES-GFP | Expresses human GPR56 and GFP in mammalian cells. |
| 52298 | pGL3E-hGPR56 e1m promoter normal | Reporter for normal human GPR56 exon 1m promoter activity. Human GPR56 e1m promoter (chr16:56,230,630-56,230,943 (hg18)) was inserted into pGL3E. |
| 52299 | pGL3E-hGPR56 e1m promoter perisylvian polymicrogyria | Reporter for mutated human GPR56 exon 1m promoter activity. It contains a 15-bp deletion in a conserved noncoding element. The mutated human GPR56 e1m promoter was inserted into pGL3E. |