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The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.

Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ
Mol Cell Biol. 2009 Feb;29(3):650-61. doi: 10.1128/MCB.00993-08. Epub 2008 Dec 1. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
49240pAc-C Med12Hisexpresses human Med12 with His tag in insect cells

Antibodies from Article