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The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.

Fransson S, Ruusala A, Aspenstrom P
Biochem Biophys Res Commun. 2006 Jun 2;344(2):500-10. Epub 2006 Apr 3. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
47892pRK5-myc-Miro1 K427VExpresses myc tagged Miro1 K427 constitutively active mutant
47893pRK5-myc-Miro1 S432NExpresses myc tagged Miro1 S432N dominant negative mutant
47894pRK5-myc-Miro1 E208K/E328KExpresses myc tagged Miro1 E208K/E328K mutant
47895pRK5-myc-Miro1 Δ593-618Expresses myc tagged Miro1 lacking transmembrane domain
47896pRK5-myc-Miro2 A13VExpresses myc tagged Miro2 A13V constitutively active mutant
47897pRK5-myc-Miro2 T18NExpresses myc tagged Miro2 T18N dominant negative mutant
47898pRK5-myc-Miro2 R425VExpresses myc tagged Miro2 R425V constitutively active mutant
47899pRK5-myc-Miro2 S430NExpresses myc tagged Miro2 S430N dominant negative mutant
47900pRK5-myc-Miro2 E208K/E328KExpresses myc tagged Miro2 V208K/E328K mutant
47901pRK5-myc-Miro2 Δ593-618Expresses myc tagged Miro2 lacking transmembrane domain

Antibodies from Article