The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi.
Chen X, Shen J, Prywes R
J Biol Chem. 2002 Apr 12. 277(15):13045-52.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 11975 | p3xFLAG-ATF6 | For mammalian expression of human ATF6 with a 3x FLAG tag |
| 32955 | pEGFP-ATF6 | For visualization of GFP-ATF6 in mammalian cells. |
| 32956 | pEGFP-ATF6-(S1P-) | For visualization of ATF6 in mammalian cells with a mutation in ATF6 that blocks cleavage by protease S1P. Activated protein will remain in the Golgi. |