An Engineered GluCl Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin.
Frazier SJ, Cohen BN, Lester HA
J Biol Chem. 2013 May 29.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 47387 | pcDNA3.1 V5 His-TOPO-GluCl optalpha-mYFP L9'F (Opt α-GluClv2.0) | allow pharmacologically induced silencing of electrical activity in CNS neurons upon exposure to the anthelmintic drug ivermectin |
| 47542 | pcDNA3.1 V5 His-TOPO-GluCl optbeta-m-YFP Y182F RSR_AAA (Opt β-Gluclv2.0) | engineered receptor improves heteromeric receptor expression and sensitivity to IVM. |