Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.

Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL
Mol Cell. 2000 Dec . 6(6):1365-75. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article