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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC
Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
44239pLHCX-FLAG-mPKM2
44240pLHCX-FLAG-mPKM1

Antibodies from Article