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Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC
Nature. 2012 Mar 25;484(7395):529-33. doi: 10.1038/nature10975. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
41806IL2 pAcGP67a
41807IL2 F42A pAcGP67a
41808IL2 pMalLP
41810H9 F42A pAcGP67a
41811H9 pMalLP
41812D10 pAcGP67a

Antibodies from Article