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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA
J Biol Chem. 2008 Jun 13;283(24):16895-905. Epub 2008 Mar 14. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
36046pT7-7 asyn WT
36048pT7-7 asyn S129A
36049pT7-7 asyn S129G
36050pT7-7 asyn S129E

Antibodies from Article