PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis.
Ilic N, Utermark T, Widlund HR, Roberts TM
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E699-708. Epub 2011 Aug 29.
(Link opens in a new window)
PubMed
(Link opens in a new window)
Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 33252 | pBabe puro-eIF4E | |
| 33253 | pBabe puro-HA-PIK3CA(H1047R;I848V) | |
| 33254 | pBabe puro-HA-PIK3CA(H1047R;G320E) | |
| 33255 | pBabe puro-HA-PIK3CA(H1047R;F486S;del) |