The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates.
Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL
J Biol Chem. 2010 Feb 26. 285(9):6308-15.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 24604 | pCMV5 MYC-Smurf2 (FF29/30A) WT | |
| 24605 | pCMV5 MYC-Smurf2 (FF29/30A) C716A | |
| 24606 | pCMV5 MYC-Smurf2 (FF29/30A, Y459A) WT | |
| 24607 | pCMV5 MYC-Smurf2 (FF29/30A, Y459A) C716A |