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Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.

Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, Hol EM, Masucci MG, Dantuma NP
J Cell Biol. 2002 Apr 29. 157(3):417-27. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
23967pcDNA3 Ub-UBB+1
23968pcDNA3 Ub2-UBB+1

Antibodies from Article