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De novo designed Hsp70 activator dissolves intracellular condensates.

Zhang JZ, Greenwood N, Hernandez J, Cuperus JT, Huang B, Ryder BD, Queitsch C, Gestwicki JE, Baker D
Cell Chem Biol. 2025 Feb 4:S2451-9456(25)00029-7. doi: 10.1016/j.chembiol.2025.01.006. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
235666pcDNA3 JDM37-GFPnb-mChExpresses designed activator of Hsp70 tagged with a GFP nano body and mCherry
235667pcDNA3 JDM16-GFPnb-mChExpresses designed inhibitor of Hsp70 tagged with a GFP nano body and mCherry

Antibodies from Article